The Ace locus of Drosophila melanogaster: structural gene for acetylcholinesterase with an unusual 5′ leader.
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چکیده
منابع مشابه
Sequence of the structural gene for xanthine dehydrogenase (rosy locus) in Drosophila melanogaster.
We determined the nucleotide sequence of a 4.6-kb EcoRI fragment containing 70% of the rosy locus. In combination with information on the 5' sequence, the gene has been sequenced in entirety. rosy cDNAs have been isolated and intron/exon boundaries have been determined. We find an open reading frame which spans four exons and would encode a protein of 1335 amino acids. The molecular weight of t...
متن کاملLocus of Drosophila Melanogaster
I N a previous paper (LIFSCHYTZ and FALK 1969b) we showed that by using the specific interaction pn-K-pn (prune--Killer-prune) we could construct an efficient screening system in which the products of reversions in the p n and K-pn loci were the only viable male-progeny. The few female progeny that survived served for estimating the number of tested zygotes. K p n is a dominant mutant, interact...
متن کاملMolecular Genetics of the ROSY-ACE Region of DROSOPHILA MELANOGASTER.
Three hundred and fifteen kilobases of DNA from the rosy-Ace region on chromosome 3R of D. melanogaster have previously been cloned and extensively characterized. We describe the isolation of nine new deficiency mutants that break within the 315-kb interval. The position of these breakpoints on the DNA map was determined by in situ and Southern hybridization. Further, we more precisely mapped t...
متن کاملPorphyrin derivatives as inhibitors for acetylcholinesterase from Drosophila melanogaster
The cure for Alzheimer's disease (AD) is still unknown. According to Cholinergic hypothesis, Alzheimer's disease is caused by the reduced synthesis of the neurotransmitter, Acetylcholine. Regional cerebral blood flow can be increased in patients with Alzheimer's disease by Acetylcholinesterase (AChE) inhibitors. In this regard, Tetraphenylporphinesulfonate (TPPS), 5,10,15,20- Tetrakis (4-sulfon...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1986
ISSN: 0261-4189
DOI: 10.1002/j.1460-2075.1986.tb04591.x